Cellular Potts Model Rho GTPase Synchrony (Low Adhesion)

Simulation Parameters
----------------------------------

Number of Cells: 373
Monte Carlo Steps: 1000
Temperature: 30

Medium-Medium Adhesion Energy: 0.0
Cell-Cell Adhesion Energy: 80.0
Cell-Medium Adhesion Energy: 60.0

Volume (Area in 2D) Constraint Parameter, lambda: 1.0
Surface (Perimeter in 2D) Constraint Parameter, lambda: 0.0

SBML Model
----------------------------------

Rho GTPase Concentration: G
Cell Area: A
Cell Target Area: AT
Time Scale: tau
Time Scale Separation Parameter: eps

dG/dt = tau * ( ( 0.1 + beta * A^10/(AT^10 + A^10) + 1.5 * G^4/(1+G^4) ) * (2 - G) - G )

dAT/dt = -1 * tau * eps * ( AT - 400 * (1 - 0.75 * G^4/(0.3^4 + G^4)) )


Model Parameter Values
----------------------------------
tau: 2000
eps: 0.1
beta: 0.2
ODE Solver step-size: 0.001
Initial GTPase Concentration, G(0): random ~ Unif(0,1)
Initial Cell Target Area, AT(0) = Initial Cell Area, A(0)