Satya Nadella Explains The Future of AI-Powered Coding and Multi-Agent Systems

Microsoft’s CEO Satya Nadella joined me for a conversation at Build 2025 to dive deep into how AI is transforming the developer experience, and the future of work.

We talked about the growing role of Copilot in writing code (it now contributes to over 30% of Microsoft’s own codebase), and what the introduction of Copilot Tuning means for developers and companies who want to train AI on their own proprietary data. Satya shared his vision for “AI squads” specialized agents that assist with tasks like email, data analysis, and ideation, and how Microsoft Teams is enabling these multi-agent systems to collaborate seamlessly.

TIMESTAMPS

00:00 – Intro: Microsoft Build & AI Highlights
00:24 – How AI Is Changing Software Development
02:51 – The Rise of AI Coworkers and Multi-Agent Systems
05:56 – Building Trust in AI Systems
08:29 – Real-World AI Use Case: Stanford’s Tumor Board Agents
10:10 – Satya Nadella on Legacy, Culture, and Microsoft’s Mission

We also explored critical questions around trust, transparency, and security in AI systems. Satya detailed how Microsoft is building safety directly into its AI engineering pipeline—from agent identity management and audit logs, to new tools like Prompt Shields and Microsoft Peer Review that help ensure responsible deployment of AI across the enterprise.

One of the most powerful stories he shared was from Stanford Medicine, where multi-agent systems are being used to enhance tumor board meetings, integrating pathology, clinical trial data, and medical literature to improve decision-making in cancer care.

Finally, I asked Satya how he hopes to look back on his legacy at Microsoft. His answer centered not on individual success, but on maintaining a culture of innovation and impact—one that stays mission-driven, no matter how much the technology changes.

This conversation offers an inside look at the tools, principles, and ideas driving Microsoft’s vision for AI—and what it means for developers, businesses, and society at large.

If you're building with AI, thinking about its impact on your work, or just curious about where we're headed—this one is worth watching.


Satya Nadella Explains The Future of AI-Powered Coding and Multi-Agent Systems

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