How Permeation Enhancer Testing Works

Chemist Andrew Day discusses our permeation enhancer testing process for transdermal systems. Learn more about our in-house analytical lab: www.tapemark.com/services/analytical-services

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Transcript:

Hello, Andrew Day back here in Tapemark laboratories. Today, I wanted to talk about permeation enhancers and how we typically test them at Tapemark laboratories. Permeation enhancers are what we use to make the drug for your API permeate through the skin for transdermal systems. The FDA and USP require that you quantitate those both for content uniformity and release and for stability.

The problem is that a lot of them are oils that have high boiling points and they're hard to quantitate on something like an HPLC, so usually, we use a GC to quantitate those permeation enhancers. Over time, we develop a trend for how those permeation enhancers change in the product and we can determine whether they're adequate for the finished product good. Thank you.